International Journal of Social Science & Economic Research
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Title:
Misinformation and Weaponization: Smallpox Inoculation in the 18th Century

Authors:
Tasbih K. Bakshi

Journal: International Journal of Social Science and Economic Research (IJSSER)
ISSN: 2455-8834
Volume: 11
Issue: 8
Publication Date: August 2026
DOI: 10.46609/IJSSER.2026.v11i08.020

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Tasbih K. Bakshi
Sidwell Friends School, Washington DC

MLA 8
Bakshi, Tasbih K. "Misinformation and Weaponization: Smallpox Inoculation in the 18th Century." Int. j. of Social Science and Economic Research, vol. 11, no. 8, Aug. 2026, pp. 3909-3918, doi.org/10.46609/IJSSER.2026.v11i08.020. Accessed Aug. 2026.
APA 6
Bakshi, T. (2026, August). Misinformation and Weaponization: Smallpox Inoculation in the 18th Century. Int. j. of Social Science and Economic Research, 11(8), 3909-3918. Retrieved from https://doi.org/10.46609/IJSSER.2026.v11i08.020
Chicago
Bakshi, Tasbih K. "Misinformation and Weaponization: Smallpox Inoculation in the 18th Century." Int. j. of Social Science and Economic Research 11, no. 8 (August 2026), 3909-3918. Accessed August, 2026. https://doi.org/10.46609/IJSSER.2026.v11i08.020.

References

[1] . Blake, John B. “Smallpox Inoculation in Colonial Boston.” Journal of the History of Medicine and Allied Sciences 8, no. 3 (1953): 284–300. http://www.jstor.org/stable/24619895.
[2] . [Douglass, Dr. William] “The History of Inoculation.” The New England Courant, August 14-21, excerpts in https://nationalhumanitiescenter.org/pds/becomingamer/ideas/text7/smallpoxinoculation.
[3] . Armstrong, Melanie. “Microbe Culture: Germ Politics and the Unseen Racial History of Nature.”In Historicizing Fear: Ignorance, Vilification, and Othering, edited by Travis D. Boyce and Winsome M. Chunnu, 52–70. University Press of Colorado, 2019. http://www.jstor.org/stable/j.ctvwh8d12.6
[4] . Minardi, Margot. “The Boston Inoculation Controversy of 1721-1722: An Incident in the History of Race.” The William and Mary Quarterly 61, no. 1 (2004): 47–76. https://doi.org/10.2307/3491675.
[5] . Rothstein, Aaron. “Vaccines and Their Critics, Then and Now.” The New Atlantis, no. 44 (2015): 3–27. http://www.jstor.org/stable/43551422.
[6] . Moore, James. The History of the Small Pox. Longman, Hurst, Rees, Orme, and Brown,1815,https://babel.hathitrust.org/cgi/pt?id=hvd.hc21dp&seq=8
[7] . The New England Courant. “Absinthium.” December 11-18, 1721, excerpts in https://nationalhumanitiescenter.org/pds/becomingamer/ideas/text7/smallpoxinoculation.
[8] . National Humanities Center Research Toolbox, “The Paper War Over Smallpox Vaccination”,
[9] . The New England Courant. “Frank Scammony.”August 21-28, 1721, excerpts in https://nationalhumanitiescenter.org/pds/becomingamer/ideas/text7/smallpoxinoculation.
[10] . Massey, Edmund. “A sermon against the dangerous and sinful practice of inoculation.” Lecture,St. Alban Woodstreet, July 8th, 1722, https://name.umdl.umich.edu/N02782.0001.001
[11] . Williams, John. “Answer to a Late Letter in the New England Courant.” Several Arguments Proving That Inoculating the Smallpox Is not Contained in the Law of Physick, Nov 13-20, 1721, excerpts in https://nationalhumanitiescenter.org/pds/becomingamer/ideas/text7/smallpoxinoculation.
[12] . Fenn, Elizabeth A. “Biological Warfare in Eighteenth-Century North America: Beyond Jeffery Amherst.” The Journal of American History 86, no. 4 (2000): 1552–80. https://www.jstor.org/stable/2567577
[13] . Adams, John. “John Adams to Abigail Adams,” June 26, 1776. Founders Online, National Archives, https://founders.archives.gov/documents/Adams/04-02-02-0013
[14] . Fenn, A, Elizabeth. Pox Americana: The Great Smallpox Epidemic of 1775-82. Hill and Wang, 1959.
[15] . Washington, George. George Washington to David Grier, March 12, 1777. George Washington's Mount Vernon. https://www.mountvernon.org/education/primary-source-collections/primary-source-collctions/article/smallpox-inoculation-letter
[16] . “Bill concerning Inoculation for Smallpox, [27 December 1777],” Virginia Assembly, (1777). Founders Online, National Archives. https://founders.archives.gov/documents/Jefferson/01-02-02-0040

ABSTRACT:
This paper examines the 18th century history of smallpox, the development and practice of smallpox inoculation, and the ways both the disease and its prevention became entangled with misinformation, prejudice, and systems of power. While smallpox was one of the deadliest infectious diseases in human history, responses to its spread were shaped not only by medical knowledge but also by political, religious, social, and racial ideologies. In addition, this paper analyzes how both smallpox and inoculation were weaponized against populations considered racially or politically inferior.

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