The HIV and AIDS pandemic posses the most significant threat to government planning
aspiration in Nigeria. In the Niger Delta the crisis is potentially devastating, one inextricably
linked to development. Poor livelihood or poverty in the view of this paper increased
vulnerability to the pandemic, while HIV prevalence hinders economic growth and development.
The paper revealed that economic, social and cultural factors have spread HIV in the Delta
region. Dealing with many dimensions of HIV and AIDS according to the study, requires an
integrated approach. All stakeholders-federal, state and local governments, the private sector,
civil society organizations and international organizations have roles to play to bring about
active preventive and curative programmes.